“Advancements in Single-Cell Transcriptomics Through Long-Read scRNA-seq, Spatial Analysis, and GPT”, Rui Chen, PhD, UCI Department of Ophthalmology
Single-cell sequencing has revolutionized the molecular profiling of tissues and organs. However, current technologies still face several limitations and challenges. In this presentation, I will discuss various technologies we have developed to address some of these limitations. To explore mRNA alternative splicing at the single-cell level, we have employed single-cell RNA sequencing using both short-read…
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Spatial Transcriptomic Data Analysis with an Emphasis on 10x Genomics Visium Workshop
This workshop will introduce data analysis workflow with both sequencing- and imaging-based spatial transcriptomics platforms, using 10x Genomics Visium and Xenium as examples. The topics will include an overview of preprocessing and data visualization with both 10x Genomics proprietary software and the state-of-the-art open-source software. New topics such as Visium HD and Xenium 5k data…
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Genetics, Biomedical Computing and Genomics Seminar Series – “Harnessing alternative polyadenylation and tandem repeat to understand the genetic basis of human diseases”
Dr. Ya (Allen) Cui is a research assistant professor in Prof. Wei Li’s lab in the Department of Biological Chemistry at the University of California Irvine. Dr. Cui will open his own lab early next year. Dr. Cui’s research is focused on understanding the genetic association of tandem repeat (TR) and alternative polyadenylation (APA) association…
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Genetics, Biomedical Computing and Genomics Seminar – Presentations from Drs. Jose Abdenur and Ray Wang from CHOC
Title “Deficient bioenergetics and antioxidant status in DARS2 deficient fibroblasts and the potential therapeutic effect of aminolevulinate/iron“ Bio Dr. Jose Abdenur is the Director of the Metabolic Laboratory at CHOC Children’s Hospital (CHOC) in Orange, CA, USA. He is a clinical professor of Pediatrics at the University of California, Irvine, and program director for Clinical…
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10x Genomics & UCI GRT Hub XeniumPrime 5K Launch Party – Registration is Required
The GRT Hub provides services and advanced tools like CytAssist for Visium, VisiumHD, and Xenium for In Situ Analysis, supporting research at UCI and beyond. Unlocking new insights into the spatial context of disease requires both depth and breadth. Depth gives researchers as much information as possible on each gene. Breadth provides a broader picture…
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Win Free Microbial Sequencing
The submission window is now open! Win free sequencing for your microbiome or metagenomics research Could your research benefit from highly accurate long-read sequencing at scale? The submission window is open for the 2024 Microbial Genomics SMRT Grant! Tell us in 100 words or less how PacBio HiFi sequencing will advance your microbiome and metagenomics…
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Genetics, Biomedical Computing and Genomics Monthly Seminar
Emerging Genetic Drivers of Human Diseases: A genome-wide spectrum of tandem repeat expansions in 338,963 humans In this talk, Dr. Li will present an extremely exciting new research direction: the Tandem Repeat Genome Aggregation Database (UCI TR-gnomAD; Cell 2024). This groundbreaking project has positioned UCI as a leader in human and medical genetics. TR-gnomAD provides the…
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Genetics, Biomedical Computing and Genomics Monthly Meeting – “Translational Science at CFCCC-Opportunities for Collaboration and Clinical Trials”, Farshid Dayyani, MD, PhD
Dr. Dayyani is a Professor of Clinical Medicine in the Division of Hematology/Oncology at University of California Irvine and board certified in Medical Oncology. He is also the Associate Director for Translational Science and the Medical Director of the Clinical Trials Unit at the Chao Family Comprehensive Cancer Center at UC Irvine. Dr. Dayyani performs…
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Spatial Transcriptomic Data Analysis and Software Workshop
This workshop will introduce data analysis workflow with both sequencing and imaging based spatial transcriptomics platforms, using 10x Visium and Xenium as examples. The topics will include an overview of data quality control, preprocessing and visualization, cellular segmentation etc. with 10x proprietary software and state of the art open-source software. A guided tour will be…
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Genetics, Biomedical Computing and Genomics Seminar – Novel Approaches to Doing Whole Genome Editing
“Eye on Genome Editing” Krzysztof Palczewski, PhD, is a UCI Distinguished Professor and Donald Bren Professor in the Departments of Ophthalmology and Physiology and Biophysics and holds the Irving H. Leopold Chair in Ophthalmology in the Gavin Herbert Eye Institute, School of Medicine, UCI. Professor Palczewski received his MS and PhD degrees from University of Wroclaw and Technical University of…
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