Genetics, Biomedical Computing and Genomics Seminar – Presentations from Drs. Jose Abdenur and Ray Wang from CHOC

Title

“Deficient bioenergetics and antioxidant status in DARS2 deficient fibroblasts and the potential therapeutic effect of aminolevulinate/iron“

Bio

Dr. Jose Abdenur is the Director of the Metabolic Laboratory at CHOC Children’s Hospital (CHOC) in Orange, CA, USA. He is a clinical professor of Pediatrics at the University of California, Irvine, and program director for Clinical Biochemical Genetics in the UCLA Intercampus Medical Genetics Training Program. He is director of the National Organization for Rare Diseases (NORD) CHOC-UCI Center of Excellence for Rare Diseases. His expertise ins in the Diagnosis and treatment of Inborn Errors of Metabolism involving small molecules, specially mitochondrial diseases.

Title

“Genome Editing for Treatment of Rare Lysosomal Storage Diseases”

Bio

Raymond Wang, MD is a board-certified clinical geneticist and biochemical genetics specialist, director of the Campbell Foundation Multidisciplinary Lysosomal Storage Disorder Program at CHOC Children’s, Orange, CA, USA, the CHOC California Institute of Regenerative Medicine Alpha Stem Cell Program, and Associate Clinical Professor of Pediatrics at the University of California-Irvine School of Medicine. Dr. Wang earned his medical degree from the University of California, Los Angeles (UCLA), where he was a member of the Alpha Omega Alpha honors society. He completed his internship and residency in medical genetics and pediatrics at Cedars-Sinai Medical Center, a fellowship in biochemical genetics at the UCLA Intercampus Training Program in 2007, and the UCLA K30 Graduate Program in Translational Investigation in 2008. Dr. Wang oversees clinical care of more than 150 patients with lysosomal storage diseases, including Neuronal Ceroid Lipofuscinoses as a part of the Batten Disease Centers of Excellence Program. His National Institutes of Health / California Institute of Regenerative Medicine-funded and Campbell Foundation Endowed Clinical / Translational Research Program aims to provide hope to patients and families with lysosomal diseases, via access to clinical trials or by conducting groundbreaking translational research to develop new therapies.